11/3/2023 0 Comments Dimethyl fumarate copay assistance![]() ![]() No dosage adjustment is necessary in patients with mild renal impairment.Because of an increase in the exposure of a major metabolite, use of VUMERITY is not recommended in patients with moderate or severe renal impairment USE IN SPECIFIC POPULATIONS Renal Impairment Eosinophilia adverse reactions: A transient increase in mean eosinophil counts was seen during the first 2 months of therapy.Discontinuations due to elevated hepatic transaminases were <1% and were similar in patients treated with dimethyl fumarate or placebo PML has occurred in patients taking dimethyl fumarate in the postmarketing setting in the presence of lymphopenia (2 times the ULN.A fatal case of PML occurred in a patient who received dimethyl fumarate for 4 years while enrolled in a clinical trial PML is an opportunistic viral infection of the brain caused by the JC virus (JCV) that typically only occurs in patients who are immunocompromised, and that usually leads to death or severe disability. Progressive multifocal leukoencephalopathy (PML) has occurred in patients with MS treated with dimethyl fumarate (which has the same active metabolite as VUMERITY).Progressive Multifocal Leukoencephalopathy Patients should be instructed to discontinue VUMERITY and seek immediate medical care should they experience signs and symptoms of anaphylaxis or angioedema ![]() Signs and symptoms in patients taking dimethyl fumarate (which has the same active metabolite as VUMERITY) have included difficulty breathing, urticaria, and swelling of the throat and tongue. VUMERITY can cause anaphylaxis and angioedema after the first dose or at any time during treatment.WARNINGS AND PRECAUTIONS Anaphylaxis and Angioedema Reactions may include anaphylaxis and angioedema They stopped abruptly offering copay assistance. That also includes the other manufacturers of the generic Tec. With known hypersensitivity to diroximel fumarate, dimethyl fumarate, or to any of the excipients of VUMERITY. I had been getting copay assistance from Mylan for the generic Tecfidera - but they just up and stopped offering assistance as of January 1st.Important Safety Information CONTRAINDICATIONS VUMERITY is contraindicated in patients VUMERITY ® (diroximel fumarate) is indicated for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.
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